Acteryon

One-stop shop for phage therapeutics and other phage technologies. We possess the expertise and state-of-the-art facilities required to support the full lifecycle of product development—from concept and phage discovery to the production of cGMP batches for clinical trials.


Acteryon’s service capabilities

Acteryon’s R&D facilities are equipped with state-of-the-art laboratories and biotechnological tools to ensure excellence in bacteriophage research and development.

External Services
Acteryon’s R&D facilities are equipped with state-of-the-art laboratories and biotechnological tools to ensure excellence in bacteriophage research and development.
Key facilities include:

• Microbiology and Quality Control Laboratories (BSL2): Supporting detailed microbial studies and quality assurance.
• Bacteriophage Laboratories (BSL2): Dedicated spaces for phage isolation, characterization, and engineering.
• Genetic Engineering Laboratory (BSL2, GMM Class II): Focused on genome editing, cloning, and protein expression.
• Chromatography Laboratory: Specialized in advanced protein and phage purification techniques.
• Bioprocess Optimization Laboratory: Innovating upstream and downstream technologies for scalable production.
• Coldroom Biobank and Central Sterilization Room: Ensuring secure storage and sterilization of samples and equipment.
Acteryon’s bioprocessing capabilities are designed to meet both research and clinical manufacturing needs, with facilities optimized for upstream and downstream production:
• Upstream (Class D Cleanrooms): Featuring fermentation and sterilization rooms for phage and recombinant protein production.
• Downstream (Class C Cleanrooms): Including TFF filtration, inoculum preparation (BSL1/BSL2), media/buffer preparation, chromatography, and quarantine cold storage.
Acteryon’s extensive biobank includes:
• Over 200 bacteriophages and bacterial hosts.
• Recombinant proteins, plasmids, and production strains.
• High-quality control strains for consistent research and manufacturing.
Acteryon excels in designing and producing next-generation biotherapeutics.
Services include:

• Phage genome investigation to design biotherapeutics.
• Engineering recombinant endolysins for stability, solubility, and enhanced enzymatic activity.
• Protein structural analysis using bioinformatics, AI algorithms, and biochemical techniques.
• Cloning and gene expression in prokaryotic systems.
• Screening, testing, and manufacturing recombinant proteins using scalable bioprocess systems (5-30-200 L bioreactors, TFF systems, and FPLC chromatography).
Acteryon specializes in the full lifecycle of phage development, including:
Isolation: From diverse sources such as soil, sewage, water, and biological samples.
Characterization: Host range, stability, genome sequencing (NGS), annotation, and lysis optimization.
Formulation: Developing stable phage-based products for applications in food safety, cosmetics, veterinary, and human therapies.
Manufacturing: Scaling up production with advanced bioreactors and purification systems while ensuring regulatory compliance through rigorous QC testing.


Acteryon’s R&D facility

Acteryon is at the forefront of harnessing the power of bacteriophages, offering cutting-edge solutions that span both research and development (R&D) and manufacturing. With an emphasis on innovation, precision, and regulatory excellence, Acteryon is shaping the future of bacteriophage technology for medical and industrial applications.

Research & Development
Acteryon’s comprehensive R&D capabilities focus on unraveling the full potential of bacteriophages.
Our key areas of expertise include:

Phage Isolation, Characterization, and Formulation: Identifying and optimizing bacteriophages tailored to specific bacterial challenges.
Phage Engineering: Developing enhanced bacteriophage strains through advanced genetic modification techniques.
Phage Genome Sequencing and Analysis: Decoding phage genomes for detailed annotation and functional insights.
Phage Genes and Proteins: Expertise in engineering, cloning, expression, modification, production, and purification.
These capabilities enable Acteryon to deliver innovative phage-based solutions for combating antibiotic-resistant bacteria, biofilm issues, and microbiota modulation.
Acteryon’s state-of-the-art manufacturing processes ensure that our phage and phage-derived products meet the highest industry standards.
Our core manufacturing strengths include:

Technology Optimization: Refining upstream and downstream processes for phage particles and recombinant phage proteins.
Scaling Up: Bioprocess scale-up for commercial-grade production of phages and recombinant proteins.
Purification Expertise: Producing highly purified phage biomass and recombinant proteins for medical and medical-related applications.
Rigorous Testing: Conducting aging, stability, and biological activity tests to ensure product efficacy.
GMP Technology Transfer: Transitioning bioprocesses to GMP standards for pharmaceutical-grade production and clinical trials.
Quality Assurance: Comprehensive regulatory, safety, and QC testing to ensure compliance and reliability of final products.
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